PCR

Polymerase Chain Reaction (PCR)

The benefit of being able to amplify, and in some instances, quantitate, copies of DNA through PCR, has yet to be displaced for its value in providing rapid and sensitive identification of single nucleotide polymorphisms (SNPs) and specific gene translocations.

Molecular PCR Offering

  • Best-in-industry turnaround time (48 hours)
  • Quantitative serial reporting for BCR/ABL transcripts (major and minor)
  • CML reporting according to the International Standard (IS)
  • Solid tumor testing available for BRAF, EGFR, KRAS and MSI
Analysis Reflex Options / Notes
ABL Kinase Domain Mutation Analysis (T315I)  
B-Cell Gene Rearrangement (IGH)  
BCR/ABL1 – Major (p210) AND Minor (p190) QUALITATIVE  
BCR/ABL1 – Major (p210) AND Minor (p190) QUANTITATIVE  
BCR/ABL1 – Major (p210) QUANTITATIVE Reporting according to International Scale (IS)
Reflex to ABL Kinase Domain Mutation Analysis
BCR/ABL1 – Minor (p190) QUANTITATIVE  
CALR Mutation Analysis Available in MPN NGS Panel
CEBPA Mutation Analysis Available in AML or Pan-Myeloid NGS Panels
FLT3-ITD Available in AML or Pan-Myeloid NGS Panels
IgHV Mutation Analysis  
JAK2 V617F Mutation Analysis Reflex to JAK2 Exon 12 Mutation Analysis
Reflex to MPL and CALR Mutation Analysis
Available in MPN NGS Panel
JAK2 Exon 12 Mutation Analysis Available in MPN NGS Panel
KIT (c-KIT) Mutation Analysis (Exons 8 and 17)  
KIT (c-KIT) Mutation Analysis (D816)  
MPL W515 K/L Mutation Analysis Available in MPN NGS Panel
NPM1 Mutation Analysis Available in AML or Pan-Myeloid NGS Panels
T-Cell Gene Rearrangement (Beta/Gamma)  

"My expectations are constantly exceeded by the turnaround time, personalized service, and collaborative approach to reach the correct diagnosis."

Desiree A. Carlson, MD
Chief of Pathology, Signature Healthcare

Discover more.

A Model Experience

With core values rooted in service and integrity, our leadership team sets the bar high.

We consistently strive to set the model for exactly how a reference laboratory should engage with both physicians and patients.

Patient-Friendly Billing

All billing is treated as in-network regardless of insurance company.

Patients are only responsible for payments according to their in-network benefit program, co-insurance and/or deductible for laboratory services.

Accredited and Certified

siParadigm is accredited by CLIA (Clinical Laboratory Improvement Amendments) and certified by CAP (College of American Pathologists).

We also hold select state licensure where required.