TC/PC

sïParadigm’s FISH TC/PC enables hospital-based pathologists to perform the Professional Component (PC) through our virtual microscopy, AI-enabled interpretation platform for hematology and solid tumors FISH testing. Generate fully customized reports branded with your facility's logo.

SCHEDULE A DEMO →
siFISH Lab — sïParadigm

Technical Component

TC

sïParadigm delivers complete FISH Technical processing with fully validated, AI-powered tools for superior accuracy and efficiency.

Professional Component

PC

Facility pathologists will have full diagnostic control, with the flexibility to choose between manual and computer-assisted modes, ensuring compliance, enhanced accuracy, and user-friendliness.

Flexible Technical Excellence

You Can Always Choose Your Mode, our sïFISH platform offers dual-mode flexibility to match your workflow

Manual Digital Analysis Mode

The industry’s first digital interface designed for total manual control and higher reimbursement. Analyze signal patterns using our proprietary, user-friendly AI tools to complete a full assessment in just 3 minutes per probe. You can always reflex to a full consult for complex cases.

Computer-Assisted Analysis Mode

Our best-in-class AI algorithms handle the heavy lifting—pre-screening, enumeration, and organization of signal data. This maximizes efficiency, leaving only the final professional sign-off to you.

siFISH TC/PC Demo Video
TC/PC
Schedule a Demo ↗
TC/PC

Operational Excellence With Full Diagnostic Control

We provide the fastest, most efficient platform for expert interpretation, ensuring clinical excellence remains in-house.

2–3 day
Guaranteed

Accelerate Your Workflow

Interpret cases anytime, anywhere with our guaranteed 2–3 business day turnaround, delivering rapid image availability that enhances clinical efficiency without compromising quality.

Access our AI-Enabled Digital Interpretation Platform

Leverage your workflow with automated cell-marking overlays and rigorous, standardized QC, fully integrated with your LIS to deliver structured, customized reporting through a single, seamless interface.

Maintain Full Diagnostic Control with Flexible Client-Centric Tools

Instantly request add-on tests or convert complex cases to a full consultation (Global) with a single click, ensuring you have the right resources for every patient.

Strategic Integration and Zero Capital Investment

Access a comprehensive menu of hematologic and solid tumor FISH panels and probes, without equipment costs, additional staffing, or laboratory infrastructure investment.

TC/PC

Validated Expertise Across Key Oncology Panels

Our service supports a deep and rigorous test menu, providing the clinical foundation required for decisive diagnostics across the most critical hematological and solid tumor malignancies.

Hematology FISH Probes

TAT 2–3 days (from sample receipt)
Panel Key FISH Probe
Chronic Myeloid Leukemia (CML) BCR/ABL1
Myelodysplastic Syndromes (MDS)
  • D5S23:D5S721/CSF1R
  • MET/CEN7
  • PTPRT/20q11
  • CEN8
  • TP53/CEN17
Acute Myeloid Leukemia (AML)
  • PML/RARA
  • KMT2A
  • NUP98
  • RUNX1T1/RUNX1
  • CBFB
Acute Lymphoblastic Leukemia (ALL)
  • BCR/ABL1
  • IGH
  • ETV6/RUNX1
  • KMT2A
Myeloproliferative Neoplasm (MPN)
  • D13S319/13q34
  • BCR/ABL1
  • PTPRT/20q11
  • CEN8
  • ETV6
Multiple Myeloma*
  • CCND1/IGH
  • 1p36/1q25
  • D13S319/13q34
  • TP53/CEN17
  • CEN9
Multiple Myeloma Reflex*
  • FGFR3/IGH
  • IGH
  • IGH/MAF
  • IGH/MAFB
Panel Key FISH Probe
Acute Promyelocytic Leukemia (APL) PML/RARA
Mantle Cell Lymphoma (MCL)** CCND1/IGH
Waldenstrom** MYB/CEN6
Polycythemia Vera
  • PTPRT/20q11
  • CEN8
  • D13S319/13q34
  • CEN9
  • 1p36/1q25
Chronic Lymphocytic Leukemia (CLL)**
  • ATM/TP53
  • CEN12/D13S319/13q34
  • CCND1/IGH
Marginal Zone Lymphoma (MZL)**
  • MET/CEN7
  • CEN3
  • CCND1/IGH
  • BIRC3/MALT1
High Grade B-Cell Lymphoma**
  • IGH/BCL2
  • BCL6
  • MYC
Follicular Lymphoma**
  • IGH/BCL2
  • BCL6
Burkitt Lymphoma** MYC
Eosinophilia
  • FGFR1/D8Z2
  • FIP1L1/CHIC2/PDGFRA
  • PDGFRB
  • PCM1/JAK2
Miscellaneous
  • MYC/IGH
  • GATA2/MECOM
*Plasma Cell Enrichment Available **B-Cell Enrichment Available

Solid Tumor FISH Panels and Probes

TAT 2–3 days (from sample receipt)
Panel Key FISH Probe
Breast Cancer HER2 / CEP17
(ASCO/CAP Guidelines)
Gastric Cancer HER2 / CEP17

How It Works

Seamless Onboarding

Get Started
  • Account setup.
  • Expert-led siFISH training.
  • Easy to follow tutorials provided through sïParadigm’s Knowledge Hub.

Technical Component

Laboratory Process
  • FISH wet lab performed
  • High-resolution, multi-spectrum, 3D images are processed by our advanced proprietary AI.
  • Cases are pre-screened by an expert for quality assurance.

Professional Component

Reporting & Results
  • Interpret findings, generate reports, and digitally sign off using integrated DocuSign.
  • Download reports.
  • Access a comprehensive dashboard via our Client Portal website.

We remain always your

Responsive Diagnostic Ecosystem
Offering Full Diagnostic Flexibility on Demand

Smooth, professional transition from manual to computer-assisted testing.

Convert the case to Global (full consultation) at any step.

Real-time notifications for required actions.

Customizable report templates with CPT* codes provided.

* The CPT codes provided are for information purposes only and are based on AMA guidelines. The billing party is solely responsible for correct CPT coding.

START Today …

Take Command of Your Diagnostic Workflow.

Experience the industry's most advanced AI-enabled workspace. Schedule a personalized walkthrough today.

REQUEST A DEMO →
Pathologist using siFISH platform — sïParadigm

Contact Us Directly

You Can Always Reach Out To:

201-599-9044 or 888-599-5227
tcpc.support@siparadigm.com

Our Client Services Team:

United States: 201-599-9044 or 888-599-5227, 201-599-9066 | cs@siparadigm.com

Puerto Rico: 888-782-5430, 866-369-4114 | cs.pr@siparadigm.com

Discover more.

A Model Experience

With core values rooted in service and integrity, our leadership team sets the bar high.

We consistently strive to set the model for exactly how a reference laboratory should engage with both physicians and patients.

Accredited and Certified

siParadigm is accredited by CLIA (Clinical Laboratory Improvement Amendments) and certified by CAP (College of American Pathologists).

We also hold select state licensure where required.