While molecular and sequencing techniques continue to evolve and uncover new aspects of disease, morphology remains the basis for our understanding of the inherent nature of cells and their architecture when viewed under a microscope.
Immunohistochemistry (IHC) and special stains, give contrast to mark cell features and expressed proteins that uncover staining patterns (algorithms) to characterize and diagnose blood and solid tumor cancers.
| IHC Panels | |
|---|---|
| Breast Panel | ER, PR, HER2, Ki67 |
| Lymphoma Panel | BCL-1, BCL-2, BCL-6, CD3, CD5, CD10, CD20, CD21, CD23, CD43, Ki-67 |
| Melanoma Panel | S-100, Melan A, Tyrosinase |
| Mismatch Repair (MMR) Panel | MLH1, MSH2, MSH6, PMS2 |
| Myeloma Panel | CD56, CD138, IgA, IgG, IgM, Kappa, Lambda |
| Neuroendocrine Panel | CD56, Chromogranin A, NSE, Synaptophysin |
Desiree A. Carlson, MD
Chief of Pathology, Signature Healthcare
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